Found 3421 of ec50 data for polymerid = 2255,2256,2257,2333 
Affinity DataEC50: 0.0300nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0630nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0900nMAssay Description:Agonist activity at human S1P4 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.100nMAssay Description:Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.134nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.150nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.178nMAssay Description:Binding potency at human S1P3 receptor by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.215nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.270nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.286nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at S1P4 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at S1P5 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.340nMAssay Description:Agonist activity at human S1P5RMore data for this Ligand-Target Pair
Affinity DataEC50: 0.360nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.360nMAssay Description:Agonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human S1P5 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.449nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.460nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.530nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.530nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMpH: 7.4Assay Description:Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.660nMAssay Description:Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.670nMAssay Description:Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.670nMAssay Description:Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Actelion Pharmaceuticals
Curated by ChEMBL
Actelion Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTPgammaS uptakeMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
University Of Virginia
Curated by ChEMBL
University Of Virginia
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.810nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
Affinity DataEC50: 0.910nMAssay Description:Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.920nMAssay Description:Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.920nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
Affinity DataEC50: 0.920nMAssay Description:Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.960nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
Affinity DataEC50: 0.980nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.980nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by F...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
